Proefschrift Kerklaan

Evidence for the use of PN in the PICU

1) Surrogate endpoints

2) Short intervention time

1) Surrogate endpoints

2) Short intervention time

5

PN group: Nitrogen balance less negative on day 1.

Standard group: decrease in plasma levels of branched amino acids (valine, leucine, isoleucine), alanine, glycine and proline on day 2

PN group: Nitrogen balance less negative on day 1.

Standard group: decrease in plasma levels of branched amino acids (valine, leucine, isoleucine), glutamine,

arginine and proline on day 2

PN group

Glucose 10-20% and amino acid 0.8 g/kg/d 33 kcal/kg

Intervention only on day 1

postoperatively afterwards EN (no PN)

PN group Glucose 20%

and amino acid 0.8 g/kg/d Intervention only on day 1

postoperatively afterwards EN (no PN)

Standard group Glucose 10% 25 kcal/kg

Intervention only on day 1

postoperatively afterwards EN (no PN)

Standard group Glucose 10%

Intervention only on day 1

postoperatively afterwards EN (no PN)

37 patients (2 months -1 year) post cardiac surgery

29 patients

(6.5 months ± 3

months) post cardiac surgery

infants after cardiac operations for congenital heart defects: the effect of early nutritional support 10 Chaloupecky, V. et al. Cor et Vasa 1994;36:26-34 The effect of early

infants following congenital heart disease surgery in extracorporeal circulation 12

parenteral nutrition on amino acid and protein metabolism in

Chaloupecky, V. et al. J Thorac Cardio-vasc Surg 1997;114:1053-60 Nitrogen balance,

3-methylhistidine excretion, and plasma amino acid profile in

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