Proefschrift Kerklaan

Chapter 7

SUPPLEMENTARY TABLES

Supplementary Table 1. Exclusion criteria for study participation Not critically ill enough to necessitate nutritional support STRONGkids score lower than 2 on PICU admission 1 Non-pediatric patients (aged 17 or older) Premature newborns (<37 weeks gestational age upon admission in the PICU) ‘Do not resuscitate’ code at the time of PICU admission Expected death within 12 hours Readmission to PICU after already having been randomized Enrollment in another intervention trial Transfer from another PICU or neonatal ICU after a stay of more than 7 days Ketoacidotic or hyperosmolar coma Inborn metabolic diseases requiring specific diet Short bowel syndrome or other conditions requiring PN for more than 7 days prior to PICU admission PICU=Pediatric Intensive Care Unit, PN=Parenteral Nutrition

Supplementary Table 2. Local protocols for initiation of PN in early PN group, in all participating centers EN was attempted as soon as possible Center On admission Day 2 Day 3 Subsequent Stay

Leuven, Belgium

Mixture of glucose 30% and Vaminolact® (Fresenius)

Addition of lipids (SMOFlipid® Fresenius)

All replaced by mixture of glucose 50% and SMOFlipid® with Vaminolact® or Vamin 18®. Increase of lipids to 100%

Glucose 50% and SMOFlipid® with Vaminolact® or Vamin 18® Pharmacy-made PN: mixture of glucose, Primene® (Baxter) and Intralipid® (Baxter, 100% of final dose). Children >30 kg Olimel® (Baxter, N5 or N4 depending on central or peripheral line) Mixture amino acids, concentrated glucose and 20% IV lipids

Rotterdam, The Nether- lands

Continuous glucose infusion with glucose intake 4-6 mg/kg/ min (< 30 kg) or 2-4 mg/kg/min (> 30 kg)

Pharmacy-made PN: mixture of glucose, Primene® (Baxter) and Intralipid® (Fresenius, 50% of final dose). Children >30 kg Olimel® (Baxter, N5 or N4 depending on central or peripheral line) Addition of 20% IV lipids (50% of final dose)

Edmonton, Canada

Continuous glucose infusion with glucose intake 3-4 mg/kg/ min

Increase of lipids to 100% Mixture amino acids and concentrated glucose

EN=Enteral Nutrition, IV=Intravenous, PN=Parenteral Nutrition

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