Proefschrift_Holstein

Chapter 4

A-I

A-II

Brain activation: ADHD OFF vs. HC

Brain activation: ADHD OFF vs. ADHD ON

y = 4

y = 4

p-values

p-values p < 0.001 (t > 3.28) cluster-level corrected p < 0.005 (t > 2.69) uncorrected

p < 0.001 (t > 3.29) uncorrected p < 0.005 (t > 2.69) uncorrected

B

Beta values

0.6

0.4

0.2

0

Betavalues striatal cluster

E ect of reward (high - low) on task- switching (switch - repeat)

- 0.2

DAT1 genotype 9R carriers

C

Response times

10R homozygotes

30

20

10

detrimental e ect bene cial e ect

Response times

0

-10

E ect of reward (high - low) on task- switching (switch - repeat)

-20

HC

ADHDOFF

ADHDON

88