Proefschrift_Holstein

Dopamine D2 receptors and cognitive flexibility

Table S3.2c Mean response times and error rates on reward and switching for the subgroup of 10R homozygotes who received sulpiride (pre)-treatment (n = 14)

High reward

Low reward

Repeat

Switch 15.68 (1.74) 320.42 (11.24) 13.32 (1.63) 310.98 (9.29) 13.14 (1.87) 329.18 (14.88)

Repeat 9.59 (1.82) 323.25 (10.4) 13.39 (2.16) 316.62 (10.32)

Switch 17.41 (2.37) 327.7 (12.03)

Errors (%) (s.e.m.) *, 1 RT (ms) (s.e.m.) + Errors (%) (s.e.m.) * RT (ms) (s.e.m.) +, 2 Errors (%) (s.e.m.) 3

9.66 (1.58)

Placebo

319.14 (10.17) 12.09 (2.11) 305.36 (8.39) 9.29 (1.76) 323.67 (12.73)

16.06 (2.32)

Bromocriptine

317.95 (10.58) 18.73 (2.64) 335.54 (15) 22.19 (3.04) 315.77 (12.04)

13.37 (2.53)

Sulpiride

RT (ms) (s.e.m.)

326.08 (12.47)

Errors (%) (s.e.m.) 4

13.69 (2.61)

17.21 (2.82)

15.39 (2.91)

Sulpiride - bromocriptine

RT (ms) (s.e.m.)

310.61 (11.39)

312.35 (10.47)

316.71 (11.98)

s.e.m. = standard error of the mean Significant effects: * Main effect of switching: F(1,13) = 22.1, p < .001], drug * switching: F(1,13) = 5.6, p < .04 + Main effect of reward F(1,13) = 7.6, p < .02; 1 main effect of switching F(1,13) = 24.4, p < .001; 2 Main effect of reward F(1,13) = 7.8, p < .02; 3 main effect of switching: F(1,13) = 5.1, p < .05; main effect of reward: F(1,13) = 19.7, p < .001; 4 main effect switching F(1,13) = 9.6, p < .009

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