Proefschrift_Holstein

Chapter 2

vmPFC

/OFC

Striatum

Amygdala

Hippocampus

VTA/SN

Midbrain:

Striato-nigral-striatal connections

Cortico-striatal connections

aPFC

Cortico-cortical connections

dlPFC

VS

M1/PMC

Ventral

striatum

nucleus

Caudate

Putamen

Figure 2.1 The organization of the midbrain, striatum and prefrontal cortex in cortico-striatal-nigral circuits Three ways by which information about rewards (red /orange), cognitive control (green) and actions (blue) can be integrated. Information can be integrated at the cortical level, by direct cortico-cortical connections, or at the level of the striatum by direct cortico-striatal interactions, e.g. the aPFC projecting to not only to the anterior (orange), but also to posterior parts of the caudate nucleus (green) or by striato-nigral-striatal connections, at the level of the midbrain. Note that the regions in this figure are scaled to relative importance to the work in this thesis, and are not true to anatomical size.

Striato-nigral-striatal connections

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