Proefschrift_Holstein

Chapter 6

Table 6.3 Discrimination training

AUD

VIS

Correct Mean (SEM)

Incorrect mean (SEM)

Correct Mean(SEM)

Incorrect mean (SEM)

Day

F(1,23)

F(1,23)

5.429 *

1

18.81 (3.07)

18.85 (2.68)

< 1

17.69 (3.02)

20.19 (3.08)

15.042 ***

2

29.13 (3.90)

20.10 (2.29)

24.19 (3.20)

24.48 (3.43)

<1

27.455 ***

3.372 ^

3

28.31 (3.45)

17.17 (2.09)

28.69 (4.41)

26.50 (3.96)

31.353 ***

4

40.96 (5.13)

22.85 (2.45)

30.33 (3.17)

29.48 (3.21)

<1

47.350 ***

11.607 **

5

44.06 (4.21)

21.54 (2.43)

38.75 (3.37)

34.46 (3.06)

75.362 ***

15.027 ***

6

45.29 (3.53)

22.44 (2.07)

42.79 (3.68)

35.77 (3.09)

54.420 ***

4.347 *

7

56.50 (6.27)

25.98 (3.10)

51.52 (4.59)

44.15 (2.65)

72.552 ***

25.108 ***

8

58.31 (4.28)

28.90 (3.68)

52.04 (4.25)

40.79 (3.73)

89.538 ***

20.971 ***

9

65.92 (5.75)

22.10 (2.39)

55.69 (5.78)

40.77 (4.13)

51.151 ***

23.008 ***

10

68.56 (7.04)

27.52 (2.91)

49.27 (4.85)

37.15 (3.42)

60.396 ***

22.899 ***

11

66.67 (6.05)

26.60 (2.51)

57.15 (7.47)

36.54 (3.93)

44.035 ***

22.500 ***

12

67.92 (5.99)

24.35 (2.47)

61.56 (6.01)

40.17 (3.56)

82.304 ***

16.281 ***

13

75.90 (6.68)

27.23 (3.13)

65.92 (6.75)

49.88 (4.67)

44.893 ***

33.093 ***

14

82.67 (8.44)

28.81 (3.22)

62.00 (5.95)

39.90 (3.67)

77.400 ***

19.949 ***

15

78.25 (5.61)

29.77 (2.51)

63.65 (6.01)

39.48 (3.67)

^ = p < 0.1, * = p < 0.05, ** = p < 0.01, *** p < 0.001, bold = significant after correction for multiple (i.e. 30) t-tests: p < 0.001

We anticipated that all animals, except for those with lesions of the AcbC would show increased flexibility in the high vs. low reward condition. To assess the role of the AcbC, we first assessed whether surgery affected rewarded task-switching performance in the sham and lesion group separately, by comparing performance on pre- and post-surgery sessions. We anticipated an effect of surgery in the lesion group, but not in the sham group. Next, we assessed group effects on rewarded task-switching performance, by directly comparing the group effect in the pre- and post-surgery sessions separately. We anticipated differences between the sham and lesion group after, but not prior to surgery.

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